Synuclein, alpha (SNCA) Peptide

Details for Product No. ABIN495356
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Protein Name
Origin
Human
(1)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN495356
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Specificity Alpha-synuclein Antibody (C-term) Blocking Peptide
Purity 100 %
Alternative Name alpha-Synuclein / SNCA
Background Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Two alternatively spliced transcripts of Alpha Synuclein have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP140) is the longer transcript and encodes the longer isoform (NACP140). This antibody specific recognizing Alpha-synuclein isoform NACP140 not NACP112.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Molecular Weight 1848.28 Da
Gene ID 6622
NCBI Accession NP_000336
UniProt P37840
Research Area Neurology
Application Notes Optimal working dilution should be determined by the investigator.
Comment

This peptide is for ABIN358993

Restrictions For Research Use only
Reconstitution Restore with 0.1 mL DI water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications West, Kapatos, OFarrell et al.: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004 (PubMed).

Yao, Gu, Nakamura et al.: "Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10810-4, 2004 (PubMed).

Pigullo, De Luca, Barone et al.: "Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor." in: Parkinsonism & related disorders, Vol. 10, Issue 6, pp. 357-62, 2004 (PubMed).

Kumru, Santamaria, Tolosa et al.: "Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations." in: Annals of neurology, Vol. 56, Issue 4, pp. 599-603, 2004 (PubMed).

Validation Images
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