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LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) Peptide

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Protein Name
(2), (2), (2), (2), (1)
Control Peptide (CP)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Specificity LATS1 Antibody (N-term) Blocking Peptide
Purity 100 %
Background LATS1 is a serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. LATS1 is a umor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. It negatively regulates G2/M transition by down-regulating CDC2 kinase activity, as well as being involved in the control of p53 expression. LATS1 affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. This protein m ay also play a role in endocrine function. This protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. Sstudies in LATS1 knockout mice show development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.Synonyms: EC=, LATS1, Large tumor suppressor homolog 1, Serine/threonine-protein kinase LATS1, WARTS, WARTS protein kinase, h-warts
Molecular Weight 2225.03 Da
Gene ID 9113
NCBI Accession NP_004681
UniProt O95835
Research Area Cancer, Apoptosis/Necrosis, Kinases/Phosphatases
Application Notes Optimal working dilution should be determined by the investigator.

This peptide is for ABIN359091

Restrictions For Research Use only
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).

Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, 2001 (PubMed).

Catalog No. ABIN495435

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