Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1) Peptide

Details for Product No. ABIN495456
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Protein Name
Origin
Human
(1)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN495456
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Specificity PRKAB1 Antibody (N-term) Blocking Peptide
Purity 100 %
Alternative Name AMPK beta-1 chain / AMPKb
Background The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non- catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta- hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Alternate names: 5'-AMP-activated protein kinase subunit beta-1, PRKAB1
Molecular Weight 1804.91 Da
Gene ID 5564
NCBI Accession NP_006244
UniProt Q9Y478
Application Notes Optimal working dilution should be determined by the investigator.
Comment

This peptide is for ABIN359113

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Expiry Date 12 months
Background publications Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, 2001 (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).

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