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Cyclin-Dependent Kinase 1 (CDK1) Peptide

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Protein Name
(13), (7), (5), (5), (5), (5), (4), (4), (2), (2), (2)
Control Peptide (CP)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Specificity CDK1 Antibody (Center) Blocking Peptide
Purity 100 %
Background CDK1 is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.Synonyms: CDC2, CDC28A, CDK1, CDKN1, Cell division control protein 2 homolog, Cell division protein kinase 1, Cyclin-dependent kinase 1, P34CDC2, p34 protein kinase
Molecular Weight 1904.58 Da
Gene ID 983
NCBI Accession NP_001777
UniProt P06493
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Restore with 0.1 mL DI water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Krämer, Mailand, Lukas et al.: "Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase." in: Nature cell biology, Vol. 6, Issue 9, pp. 884-91, 2004 (PubMed).

Dai, Yamasaki, Yang et al.: "Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation." in: The Journal of investigative dermatology, Vol. 122, Issue 6, pp. 1356-64, 2004 (PubMed).

Litvak, Argov, Dahan et al.: "Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion." in: Molecular cell, Vol. 14, Issue 3, pp. 319-30, 2004 (PubMed).

Shapira, Ben-Izhak, Bishara et al.: "Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma." in: Cancer, Vol. 100, Issue 8, pp. 1615-21, 2004 (PubMed).

Chow, Siu, Ho et al.: "Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 40815-28, 2003 (PubMed).

Catalog No. ABIN495889

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