Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Peptide

Details for Product No. ABIN496182
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Protein Name
Origin
Human
(4)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN496182
176.00 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Specificity HIF1Alpha Antibody (C-term) Blocking Peptide
Purity 100 %
Alternative Name HIF1A / HIF1 alpha
Background Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT).
Alternate names: ARNT-interacting protein, BHLHE78, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, HIF-1 alpha, Hypoxia-inducible factor 1 alpha, Member of PAS protein 1
Molecular Weight 1759.41 Da
Gene ID 3091
NCBI Accession NP_001521
UniProt Q16665
Application Notes Optimal working dilution should be determined by the investigator.
Comment

This peptide is for ABIN360059

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Expiry Date 12 months
Background publications Linke, Stojkoski, Kewley et al.: "Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor." in: The Journal of biological chemistry, Vol. 279, Issue 14, pp. 14391-7, 2004 (PubMed).

Favaro, Nardo, Persano et al.: "Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death." in: The American journal of pathology, Vol. 173, Issue 4, pp. 1186-201, 2008 (PubMed).

Alexandru, Graumann, Smith et al.: "UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover." in: Cell, Vol. 134, Issue 5, pp. 804-16, 2008 (PubMed).

Validation Images
back to top