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Details for Product No. ABIN496191

Caveolin 1, Caveolae Protein, 22kDa (CAV1) Peptide

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Protein Name
Synonyms BSCL3, CGL3, MSTP085, PPH3, VIP21, caveolin 1, Caveolin-1, fc07c04, wu:fc07c04, Cav-1, bscl3, cav1, cav1a, cgl3, vip21, cav1b, caveolin-1, cav, mstp085, CAV1, cav-1
Control Peptide (CP)
Pubmed 5 references available
Catalog no. ABIN496191
Quantity 0.1 mg
165.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Specificity CAV1 Antibody Blocking Peptide
Alternative Name Caveolin-1
Background The scaffolding protein CAV1 is the main component of the caveolae plasma membranes found in most cell types. This protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The CAV1 gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade.
Alternate names: CAV1
Molecular Weight 2008.68 Da.
Gene ID 857
NCBI Accession NP_001744.2
UniProt Q03135
Research Area Signaling
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL DI water
Concentration 1,0 mg/mL
Buffer Lyophilized with 100% acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Schlegel, Arvan, Lisanti: "Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 4398-408, 2001 (PubMed).

Lee, Woodman, Engelman et al.: "Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14)." in: The Journal of biological chemistry, Vol. 276, Issue 37, pp. 35150-8, 2001 (PubMed).

Di Vizio, Adam, Kim et al.: "Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 14, pp. 2257-67, 2008 (PubMed).

Smith, Campos, Wandinger-Ness et al.: "Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating." in: Journal of virology, Vol. 82, Issue 19, pp. 9505-12, 2008 (PubMed).

Zhong, Smart, Weksler et al.: "Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 31, pp. 7788-96, 2008 (PubMed).

Alternatives for antigen "Caveolin 1, Caveolae Protein, 22kDa (CAV1)", type "Peptides"
Reactivities (1), (1), (1), (1), (1)