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Pim-1 Oncogene (PIM1) Peptide

Details for Product No. ABIN496393, Supplier: Login to see New
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Protein Name
Control Peptide (CP)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Specificity PIM1 Antibody Blocking Peptide
Purity 100 %
Background PIM1, which belongs to the Serine/Threonine protein kinase family, is thought to play a role in signal transduction in blood cells. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer. It may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. PIM1 is expressed primarily in cells of the hematopoietic and germ line lineages.Synonyms: Pim-1, Proto-oncogene serine/threonine-protein kinase pim-1
Gene ID 5292
NCBI Accession NP_002639
UniProt P11309
Research Area Cancer, Hematopoietic Progenitors
Application Notes Optimal working dilution should be determined by the investigator.

This peptide is for ABIN360328

Restrictions For Research Use only
Reconstitution Restore with 0.1 mL DI water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Pasqualucci, Neumeister, Goossens et al.: "Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas." in: Nature, Vol. 412, Issue 6844, pp. 341-6, 2001 (PubMed).

Koike, Maita, Taira et al.: "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)." in: FEBS letters, Vol. 467, Issue 1, pp. 17-21, 2000 (PubMed).

Telerman, Amson, Zakut-Houri et al.: "Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity." in: Molecular and cellular biology, Vol. 8, Issue 4, pp. 1498-503, 1988 (PubMed).

Reeves, Spies, Kiefer et al.: "Primary structure of the putative human oncogene, pim-1." in: Gene, Vol. 90, Issue 2, pp. 303-7, 1990 (PubMed).

Catalog No. ABIN496393

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