Pim-1 Oncogene (PIM1) Peptide

Details for Product No. ABIN496393
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Protein Name
Application
Control Peptide (CP)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN496393
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Specificity PIM1 Antibody Blocking Peptide
Alternative Name PIM1
Background PIM1, which belongs to the Serine/Threonine protein kinase family, is thought to play a role in signal transduction in blood cells. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer. It may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. PIM1 is expressed primarily in cells of the hematopoietic and germ line lineages.
Alternate names: Pim-1, Proto-oncogene serine/threonine-protein kinase pim-1
Gene ID 5292
NCBI Accession NP_002639
UniProt P11309
Research Area Cancer, Hematopoietic Progenitors
Comment

This peptide is for ABIN360328

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL DI water
Concentration 1,0 mg/mL
Buffer Lyophilized with 100% acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Reeves, Spies, Kiefer et al.: "Primary structure of the putative human oncogene, pim-1." in: Gene, Vol. 90, Issue 2, pp. 303-7, 1990 (PubMed).

Telerman, Amson, Zakut-Houri et al.: "Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity." in: Molecular and cellular biology, Vol. 8, Issue 4, pp. 1498-503, 1988 (PubMed).

Koike, Maita, Taira et al.: "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)." in: FEBS letters, Vol. 467, Issue 1, pp. 17-21, 2000 (PubMed).

Pasqualucci, Neumeister, Goossens et al.: "Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas." in: Nature, Vol. 412, Issue 6844, pp. 341-6, 2001 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

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