Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) Peptide

Details for Product No. ABIN496505
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Protein Name
Origin
Human
(1), (1)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN496505
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Specificity GNA12 Antibody Blocking Peptide
Purity 100 %
Alternative Name G protein subunit alpha 12 / GNA12
Background Guanine nucleotide-binding proteins (G proteins) are modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 subunits, alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Alternate names: G alpha-12, Guanine nucleotide-binding protein subunit alpha-12
Molecular Weight 1623.36 Da
Gene ID 2768
NCBI Accession NP_031379
UniProt Q03113
Application Notes Optimal working dilution should be determined by the investigator.
Comment

This peptide is for ABIN360476

Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Expiry Date 12 months
Background publications Suzuki, Nakamura, Mano et al.: "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 733-8, 2003 (PubMed).

Yamaguchi, Katoh, Negishi: "N-terminal short sequences of alpha subunits of the G12 family determine selective coupling to receptors." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 14936-9, 2003 (PubMed).

Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).

Hillier, Fulton, Fulton et al.: "The DNA sequence of human chromosome 7. ..." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Krakstad, Ardawatia, Aragay: "A role for Galpha12/Galpha13 in p120ctn regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10314-9, 2004 (PubMed).

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