Engrailed Homeobox 2 (EN2) Peptide

Details for Product No. ABIN497021
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Protein Name
Origin
Human
(1), (2), (1), (1)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN497021
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Specificity EN2 Antibody (N-term) Blocking Peptide
Purity 100 %
Alternative Name engrailed-2 / EN2
Background EN2 is thought to have a role in controlling development. In Drosophila, the protein plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. This protein has been implicated in the control of pattern formation during development of the central nervous system.
Alternate names: EN-2, Homeobox protein engrailed-2, Hu-En-2
Molecular Weight 1789.44 Da
Gene ID 2020
NCBI Accession NP_001418
UniProt P19622
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL deionized water
Concentration 1.0 mg/mL
Buffer Lyophilized with 100 % acetonitrile
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Poole, Law, Kao et al.: "Isolation and chromosomal localization of the human En-2 gene." in: Genomics, Vol. 4, Issue 3, pp. 225-31, 1989 (PubMed).

Benayed, Gharani, Rossman et al.: "Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus." in: American journal of human genetics, Vol. 77, Issue 5, pp. 851-68, 2005 (PubMed).

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