Mitogen-Activated Protein Kinase Kinase Kinase 5 (MAP3K5) Peptide

Details for Product No. ABIN499346
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Protein Name
Synonyms ASK1, MEKK5, MAPKKK5, 7420452D20Rik, ASK, Mekk5, MAP3K5, mitogen-activated protein kinase kinase kinase 5, MUD21.11, MUD21_11
Origin
Human
(6)
Application
Control Peptide (CP)
Pubmed 5 references available
Catalog no. ABIN499346
Quantity 50 µg
Price
170.50 $   Plus shipping costs $45.00
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Specificity 16 amino acids near the carboxy terminus of human ASK1.
Alternative Name MEKK5 / ASK1
Background Alternate names: Apoptosis signal-regulating kinase 1, MAP3K5, MAPK/ERK kinase kinase 5, MAPKKK5, Mitogen-activated protein kinase kinase kinase 5
Gene ID 4217
NCBI Accession NP_005914.1
UniProt Q99683
Application Notes ASK1 peptide (C2) is used for blocking the activity of ASK1 antibody. It usually blocks theantibody activity completely in Western blot by incubating the peptide with equal volumeof antibody for 30 min at 37°C. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20°C.
Expiry Date 12 months
Background publications Wang, Diener, Jannuzzi et al.: "Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase." in: The Journal of biological chemistry, Vol. 271, Issue 49, pp. 31607-11, 1997 (PubMed).

van Kooten, Banchereau: "CD40-CD40 ligand." in: Journal of leukocyte biology, Vol. 67, Issue 1, pp. 2-17, 2000 (PubMed).

Kuai, Nickbarg, Wooters et al.: "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14363-9, 2003 (PubMed).

Grech, Amesbury, Chan et al.: "TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells." in: Immunity, Vol. 21, Issue 5, pp. 629-42, 2004 (PubMed).

Davies, Mak, Young et al.: "TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells." in: Molecular and cellular biology, Vol. 25, Issue 22, pp. 9806-19, 2005 (PubMed).

Reactivities (6)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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