Bruton Agammaglobulinemia tyrosine Kinase (BTK) Peptide

Details for Product No. ABIN499506
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Protein Name
Origin
Human
(2)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 6 references available
Quantity 50 μg
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Catalog No. ABIN499506
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Specificity 16 amino acids near the amino terminus of human BTK (NT).
Purification purified
Alternative Name BTK
Background Synonyms: AGMX1, ATK, Agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase, BPK, Bruton tyrosine kinase, Tyrosine-protein kinase BTK
Gene ID 695
NCBI Accession NP_000052
UniProt Q06187
Research Area Immunology, Innate Immunity, Tyrosine Kinases
Application Notes Casp-6 peptide is used for blocking the activity of BTK antibody. It usually blocks theantibody activity completely in immunoblot analysis by incubating the peptide with equalvolume of antibody for 30 min at 37 °C.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.2 mg/mL
Buffer PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C.
Background publications Fukui, Goto, Tabata: "Two antimicrobial flavanones from the leaves of Glycyrrhiza glabra." in: Chemical & pharmaceutical bulletin, Vol. 36, Issue 10, pp. 4174-6, 1989 (PubMed).

Deveraux, Takahashi, Salvesen et al.: "X-linked IAP is a direct inhibitor of cell-death proteases." in: Nature, Vol. 388, Issue 6639, pp. 300-4, 1997 (PubMed).

Deveraux, Leo, Stennicke et al.: "Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases." in: The EMBO journal, Vol. 18, Issue 19, pp. 5242-51, 1999 (PubMed).

Holcik, Yeh, Korneluk et al.: "Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death." in: Oncogene, Vol. 19, Issue 36, pp. 4174-7, 2000 (PubMed).

Schimmer: "Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice." in: Cancer research, Vol. 64, Issue 20, pp. 7183-90, 2004 (PubMed).

Albaladejo, Alonso, Yus: "Synthesis of indolizines and heterocyclic chalcones catalyzed by supported copper nanoparticles." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 19, Issue 17, pp. 5242-5, 2013 (PubMed).

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