Caspase 12 (CASP12) Peptide

Details for Product No. ABIN499548
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Protein Name
Origin
Mouse (Murine)
(4)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 4 references available
Quantity 50 μg
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Specificity 17 amino acids near the center of mouse Caspase-12.
Purification purified
Alternative Name Caspase-12
Background Synonyms: CASP-12, CASP12, Inactive caspase-12
Gene ID 12364
NCBI Accession NP_033938
UniProt O08736
Research Area Apoptosis/Necrosis
Application Notes Caspase-12 peptide is used for blocking the antibody activity of caspase-12. It usuallyblocks the antibody activity completely in Western blot by incubating the peptide withequal volume of antibody for 30 min at 37 °C.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.2 mg/mL
Buffer PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C.
Background publications Imazu, Shimizu, Tagami et al.: "Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability." in: Oncogene, Vol. 18, Issue 32, pp. 4523-9, 1999 (PubMed).

Yasuda, Han, Dionne et al.: "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3." in: Cancer research, Vol. 59, Issue 3, pp. 533-7, 1999 (PubMed).

Chen, Cizeau, Vande Velde et al.: "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins." in: The Journal of biological chemistry, Vol. 274, Issue 1, pp. 7-10, 1999 (PubMed).

Matsushima, Fujiwara, Takahashi et al.: "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3." in: Genes, chromosomes & cancer, Vol. 21, Issue 3, pp. 230-5, 1998 (PubMed).

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Catalog No. ABIN499548
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