Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) Peptide

Details for Product No. ABIN499761
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Protein Name
Origin
Human
(1), (1)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 4 references available
Quantity 50 µg
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Catalog No. ABIN499761
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Specificity 19 amino acids near the carboxy terminus of human DR4.
Purification purified
Alternative Name CD261 / TRAILR1
Background Alternate names: APO2, DR4, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL receptor 1, TRAIL-R1, Tumor necrosis factor receptor superfamily member 10A
Gene ID 8797
NCBI Accession NP_003835
UniProt O00220
Research Area Signaling, Apoptosis/Necrosis
Application Notes DR4 peptide is used for blocking the activity of Anti-DR4. Incubating the peptide with equalvolume of antibody for 30 min at 37°C usually completely blocks the antibody activity inWestern blotting. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1 % bovine serum albumin and 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C.
Expiry Date 12 months
Background publications Black, Rauch, Kozlosky et al.: "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells." in: Nature, Vol. 385, Issue 6618, pp. 729-33, 1997 (PubMed).

Moss, Jin, Milla et al.: "Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha." in: Nature, Vol. 385, Issue 6618, pp. 733-6, 1997 (PubMed).

Peschon, Slack, Reddy et al.: "An essential role for ectodomain shedding in mammalian development." in: Science (New York, N.Y.), Vol. 282, Issue 5392, pp. 1281-4, 1998 (PubMed).

Mizui, Yamazaki, Sagane et al.: "cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter." in: Gene, Vol. 233, Issue 1-2, pp. 67-74, 1999 (PubMed).

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