Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1) Peptide

Details for Product No. ABIN500049
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Protein Name
Origin
Human
(1), (1), (9), (2), (1), (1)
Source
Synthetic
Application
Control Peptide (CP)
Pubmed 6 references available
Quantity 50 µg
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Catalog No. ABIN500049
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Specificity 15 amino acids near the amino terminus of human IRE1p.
Purification purified
Alternative Name ERN1 / IRE1
Background Alternate names: Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, IRE1p, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1
Gene ID 2081
NCBI Accession NP_001424
UniProt O75460
Application Notes IRE1p peptide is used for blocking the activity of IRE1p antibody. It usually blocks theantibody activity completely in Western blot by incubating the peptide with equal volumeof antibody for 30 min at 37°C. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1 % bovine serum albumin and 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C.
Expiry Date 12 months
Background publications Alexopoulou, Holt, Medzhitov et al.: "Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3." in: Nature, Vol. 413, Issue 6857, pp. 732-8, 2001 (PubMed).

Janeway, Medzhitov: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, 2002 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

McGettrick, ONeill: "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction." in: Molecular immunology, Vol. 41, Issue 6-7, pp. 577-82, 2004 (PubMed).

Wang, Town, Alexopoulou et al.: "Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis." in: Nature medicine, Vol. 10, Issue 12, pp. 1366-73, 2004 (PubMed).

Guillot, Le Goffic, Bloch et al.: "Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus." in: The Journal of biological chemistry, Vol. 280, Issue 7, pp. 5571-80, 2005 (PubMed).

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