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MAF1 Homolog (S. Cerevisiae) (MAF1) (Center) Peptide

Details for Product No. ABIN688109, Supplier: Log in to see
Protein Name
  • 1110068E11Rik
  • AU042856
  • maf1
  • MAF1 homolog (S. cerevisiae)
  • MAF1 homolog (yeast)
  • MAF1
  • Maf1
  • maf1-pending
Protein Region
Center
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Kantidakis, Ramsbottom, Birch, Dowding, White: "mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 26, pp. 11823-8, 2010 (PubMed).

Shor, Wu, Shakey, Toral-Barza, Shi, Follettie, Yu: "Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells." in: The Journal of biological chemistry, Vol. 285, Issue 20, pp. 15380-92, 2010 (PubMed).

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).