ALX Homeobox 4 (ALX4) (Center) Peptide

Details for Product No. ABIN688305
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Protein Name
Synonyms im:7142878, zgc:162606, alx4, FND2, lst
Protein Region
Center
Source
Synthetic
Antibody Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN688305
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Immunogen Synthetic peptide
Alternative Name ALX4
Background This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2), an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism, suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS), a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq].
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Drenos, Talmud, Casas et al.: "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk." in: Human molecular genetics, Vol. 18, Issue 12, pp. 2305-16, 2009 (PubMed).

Chang, Mohabir, Done et al.: "Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer." in: Journal of clinical pathology, Vol. 62, Issue 10, pp. 908-14, 2009 (PubMed).

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