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Lysine (K)-Specific Demethylase 2A (KDM2A) (N-Term) Peptide

Details for Product No. ABIN688361, Supplier: Log in to see
Protein Name
  • 5530401A10Rik
  • 100043628
  • AA589516
  • AW536790
  • CXXC8
  • Cxxc8
  • Fbl7
  • FBL7
  • Fbl11
  • FBL11
  • FBXL11
  • Fbxl11
  • Gm4560
  • Jhdm1
  • JHDM1A
  • Jhdm1a
  • KDM2A
  • lalina
  • LILINA
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP1043a was selected from the N-term region of human JHDM1a/FBXL11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background JHDM1a/FBXL11 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. JHDM1a/FBXL11 belongs to the Fbls class and, in addition to an F-box, contains at least 6 highly degenerated leucine-rich repeats.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Tsukada, Fang, Erdjument-Bromage, Warren, Borchers, Tempst, Zhang: "Histone demethylation by a family of JmjC domain-containing proteins." in: Nature, Vol. 439, Issue 7078, pp. 811-6, 2006

Andersen, Lam, Leung, Ong, Lyon, Lamond, Mann: "Nucleolar proteome dynamics." in: Nature, Vol. 433, Issue 7021, pp. 77-83, 2005