|+1 404 474 4654|
|+1 888 205 9894 (TF)|
APOBEC1 Complementation Factor (A1CF) (C-Term) Peptide
|Synonyms||ACF, ASP, ACF64, ACF65, APOBEC1CF, MGC163391, RP11-564C4.2, Acf, 1810073H04Rik, A1cft, Apobec-1, A1CF, DKFZp469H226, acf, asp, acf64, acf65, MGC81834, apobec1cf|
|5 references available|
|Price||49.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Characteristics||Blocking peptide for ACF (C-term) antibody ABIN654627|
Background: Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Blanc, Kennedy, Davidson: "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41198-204, 2003 (PubMed).
Xie, Sowden, Dance et al.: "The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 21, pp. 8114-9, 2004 (PubMed).
Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).
Blanc, Henderson, Newberry et al.: "Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality." in: Molecular and cellular biology, Vol. 25, Issue 16, pp. 7260-9, 2005 (PubMed).
Galloway, Smith: "The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 659-63, 2010 (PubMed).