APOBEC1 Complementation Factor (A1CF) (C-Term) Peptide

Details for Product No. ABIN688594
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Protein Name
Synonyms ACF, ACF64, ACF65, APOBEC1CF, ASP, Acf, 1810073H04Rik, A1cft, Apobec-1, acf, acf64, acf65, apobec1cf, asp, A1CF
Protein Region
C-Term
Application
Blocking Peptide (BP)
Pubmed 5 references available
Catalog no. ABIN688594
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide
Alternative Name ACF
Background Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.
Comment

Background: Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Blanc, Kennedy, Davidson: "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41198-204, 2003 (PubMed).

Xie, Sowden, Dance et al.: "The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 21, pp. 8114-9, 2004 (PubMed).

Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10...." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).

Blanc, Henderson, Newberry et al.: "Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality." in: Molecular and cellular biology, Vol. 25, Issue 16, pp. 7260-9, 2005 (PubMed).

Galloway, Smith: "The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 659-63, 2010 (PubMed).

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