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UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 6 (B4GALT6) (C-Term) Peptide

Details for Product No. ABIN688623, Supplier: Log in to see
Protein Name
  • B4Gal-T6
  • beta4Gal-T6
  • AA536803
  • AU022389
  • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
  • UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
  • B4GALT6
  • B4galt6
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose, all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Landers, Melki, Meininger, Glass, van den Berg, van Es, Sapp, van Vught, McKenna-Yasek, Blauw, Cho, Polak, Shi, Wills, Broom, Ticozzi, Silani, Ozoguz, Rodriguez-Leyva, Veldink, Ivinson, Saris, Hosler, Barnes-Nessa, Couture, Wokke, Kwiatkowski, Ophoff, Cro: "Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 22, pp. 9004-9, 2009 (PubMed).

Gevaert, Goethals, Martens, Van Damme, Staes, Thomas, Vandekerckhove: "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." in: Nature biotechnology, Vol. 21, Issue 5, pp. 566-9, 2003 (PubMed).

Takizawa, Nomura, Wakisaka, Yoshizuka, Aoki, Arai, Inoue, Hattori, Matsuo: "cDNA cloning and expression of human lactosylceramide synthase." in: Biochimica et biophysica acta, Vol. 1438, Issue 2, pp. 301-4, 1999 (PubMed).