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H2A Histone Family, Member Y2 (H2AFY2) (N-Term) Peptide

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Protein Name
Protein Region
N-Term
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 3 references available
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Quantity 0.1 mg
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Immunogen Synthetic peptide
Background Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Xu, Zheng, Isaacs et al.: "Inherited genetic variant predisposes to aggressive but not indolent prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 5, pp. 2136-40, 2010 (PubMed).

Sporn, Kustatscher, Hothorn et al.: "Histone macroH2A isoforms predict the risk of lung cancer recurrence." in: Oncogene, Vol. 28, Issue 38, pp. 3423-8, 2009 (PubMed).

Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).

Catalog No. ABIN688655

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