Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK) (Center) Peptide

Details for Product No. ABIN688660
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Protein Name
Protein Region
Center
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 2 references available
Quantity 0.1 mg
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Immunogen Synthetic peptide
Alternative Name IBTK
Background The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Spatuzza, Schiavone, Di Salle et al.: "Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk." in: Nucleic acids research, Vol. 36, Issue 13, pp. 4402-16, 2008 (PubMed).

Mungall, Palmer, Sims et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, 2003 (PubMed).

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Catalog No. ABIN688660
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