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Mitogen-Activated Protein Kinase 8 (MAPK8) (Thr183), (Tyr185) Peptide

Details for Product No. ABIN688872, Supplier: Log in to see
Protein Name
  • AI849689
  • Bsk
  • BSK
  • BSK/DJNK
  • c-Jun
  • CG5680
  • D-JNK
  • D-junk
  • DBSK/JNK
  • dJNK
  • DJNK
  • DJNK/bsk
  • Dmel\\CG5680
  • jnk
  • JNK
  • Jnk
  • JNK-46
  • JNK/SAPK
  • JNK1
  • jnk1
  • JNK1A2
  • JNK21B1/2
  • Junk
  • mapk8
  • Prkm8
  • PRKM8
  • sapk1
  • SAPK1
  • SAPK1c
  • SAPKa
  • T10F20.15
  • zgc:112379
Protein Region
Thr183, Tyr185
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Dasgupta, Kar, Liu, Joseph, Kalyanaraman, Remington, Chen, Melendez: "Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 52-62, 2010 (PubMed).

Han, Crowe: "Jun amino-terminal kinase 1 activation promotes cell survival in ErbB2-positive breast cancer." in: Anticancer research, Vol. 30, Issue 9, pp. 3407-12, 2010 (PubMed).

Yang, Zheng, Cao, Xiang, Liu, Lv: "8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK." in: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3385-93, 2010 (PubMed).