You are viewing an incomplete version of our website. Please click to reload the website as full version.

Lysyl-tRNA Synthetase (KARS) (N-Term) Peptide

Details for Product No. ABIN689037, Supplier: Log in to see
Protein Name
  • CG12141
  • Dmel\\CG12141
  • KRS
  • LysRS
  • cb530
  • wu:fa16h02
  • zgc:92483
  • kars
  • MGC53345
  • kars2
  • krs
  • krs-1
  • KARS
  • Tb06.28P18.190
  • CMTRIB
  • DFNB89
  • KARS1
  • KARS2
  • AA589550
  • AL024334
  • AL033315
  • AL033367
  • D8Ertd698e
  • D8Wsu108e
  • mKIAA0070
  • Lysyl-tRNA synthetase
  • lysyl-tRNA synthetase
  • Aats-lys
  • kars
  • Bm1_16500
  • lysS
  • Taci_1118
  • Tpau_1737
  • Arch_0261
  • Trad_2960
  • Spirs_3699
  • KARS
  • LOC100280510
  • Tb927.6.1510
  • Kars
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Background Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications McLaughlin, Sakaguchi, Liu, Igarashi, Pehlivan, Chu, Iyer, Cruz, Cherukuri, Hansen, Mullikin, , Biesecker, Wilson, Ionasescu, Nicholson, Searby, Talbot, Vance, Züchner, Szigeti, Lupski, Hou, Green, Antonellis: "Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy." in: American journal of human genetics, Vol. 87, Issue 4, pp. 560-6, 2010 (PubMed).

Kawamata, Magrané, Kunst, King, Manfredi: "Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28321-8, 2008 (PubMed).