Lysyl-tRNA Synthetase (KARS) (N-Term) Peptide

Details for Product No. ABIN689037, Supplier: Log in to see
Protein Name
  • CG12141
  • Dmel\\CG12141
  • KRS
  • LysRS
  • cb530
  • wu:fa16h02
  • zgc:92483
  • kars
  • MGC53345
  • kars2
  • krs
  • krs-1
  • KARS
  • Tb06.28P18.190
  • DFNB89
  • KARS1
  • KARS2
  • AA589550
  • AL024334
  • AL033315
  • AL033367
  • D8Ertd698e
  • D8Wsu108e
  • mKIAA0070
  • Lysyl-tRNA synthetase
  • lysyl-tRNA synthetase
  • Aats-lys
  • kars
  • Bm1_16500
  • lysS
  • Taci_1118
  • Tpau_1737
  • Arch_0261
  • Trad_2960
  • Spirs_3699
  • KARS
  • LOC100280510
  • Tb927.6.1510
  • Kars
Protein Region
Peptide Type
Blocking Peptide (BP)
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Background Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications McLaughlin, Sakaguchi, Liu, Igarashi, Pehlivan, Chu, Iyer, Cruz, Cherukuri, Hansen, Mullikin, , Biesecker, Wilson, Ionasescu, Nicholson, Searby, Talbot, Vance, Züchner, Szigeti, Lupski, Hou, Green, Antonellis: "Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy." in: American journal of human genetics, Vol. 87, Issue 4, pp. 560-6, 2010 (PubMed).

Kawamata, Magrané, Kunst, King, Manfredi: "Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28321-8, 2008 (PubMed).