Lysyl-tRNA Synthetase (KARS) (N-Term) Peptide

Details for Product No. ABIN689037
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Protein Name
Synonyms
CMTRIB, DFNB89, KARS1, KARS2, KRS, LysRS, AA589550, AL024334, AL033315, AL033367, D8Wsu108e, mKIAA0070, D8Ertd698e, CG12141, Dmel\\CG12141, cb530, wu:fa16h02, zgc:92483, kars, MGC53345, kars2, krs, kr ... show more
CMTRIB, DFNB89, KARS1, KARS2, KRS, LysRS, AA589550, AL024334, AL033315, AL033367, D8Wsu108e, mKIAA0070, D8Ertd698e, CG12141, Dmel\\CG12141, cb530, wu:fa16h02, zgc:92483, kars, MGC53345, kars2, krs, krs-1, KARS, Tb06.28P18.190 show less
Protein Region
N-Term
Application
Blocking Peptide (BP)
Pubmed 2 references available
Catalog no. ABIN689037
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Alternative Name KARS
Background Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Comment

Background: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Kawamata, Magrané, Kunst et al.: "Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28321-8, 2008 (PubMed).

McLaughlin, Sakaguchi, Liu et al.: "Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy." in: American journal of human genetics, Vol. 87, Issue 4, pp. 560-6, 2010 (PubMed).

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