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Lysyl-tRNA Synthetase (KARS) (N-Term) Peptide

Name

Lysyl-tRNA Synthetase (KARS)
Synonyms
KRS, KARS2, KIAA0070, CG12141, DmelCG12141, LysRS, AA589550, AL024334, AL033315, AL033367, D8Wsu108e, mKIAA0070, D8Ertd698e, cb530, zgc:92483, kars, MGC53345, krs, kars2, krs-1, MGC52992, KARS, MGC127 ... show more
Binding Site

N-Term
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN689037
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for KARS (N-term) antibody ABIN655049
Comments

Background: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms KRS, KARS2, KIAA0070, CG12141, DmelCG12141, LysRS, AA589550, AL024334, AL033315, AL033367, D8Wsu108e, mKIAA0070, D8Ertd698e, cb530, zgc:92483, kars, MGC53345, krs, kars2, krs-1, MGC52992, KARS, MGC127504, DKFZp468A0216, MGC94484, MGC69375, Tb06.28P18.190

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Kawamata, Magrané, Kunst et al.: "Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28321-8, 2008 (PubMed).

McLaughlin, Sakaguchi, Liu et al.: "Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy." in: American journal of human genetics, Vol. 87, Issue 4, pp. 560-6, 2010 (PubMed).