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Autophagy Related 12 (ATG12) (N-Term) Peptide

Details for Product No. ABIN689462, Supplier: Log in to see
Protein Name
  • 4931423H11Rik
  • A330058M13Rik
  • APG12
  • Apg12l
  • APG12L
  • Atg12l
  • FBR93
  • HAPG12
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG12L is the human homolog of yeast APG12, a ubiquitin-activating enzyme E1-like protein essential for the conjugation system that mediates membrane fusion in autophagy.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Tanida, Nishitani, Nemoto, Ueno, Kominami: "Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing." in: Biochemical and biophysical research communications, Vol. 296, Issue 5, pp. 1164-70, 2002 (PubMed).

Tanida, Tanida-Miyake, Komatsu, Ueno, Kominami: "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13739-44, 2002 (PubMed).

Mizushima, Sugita, Yoshimori, Ohsumi: "A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy." in: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 33889-92, 1999 (PubMed).

Ueno, Kumagai, Kijima, Kishimoto, Hosoe: "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer." in: Human genetics, Vol. 102, Issue 1, pp. 63-8, 1998 (PubMed).