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POU Class 5 Homeobox 1 (POU5F1) (Cys279) Peptide

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Protein Name
Protein Region
Peptide Type Synthetic
Blocking Peptide (BP)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Synthetic peptide
Background This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6,22)(p21,q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Abu-Remaileh, Gerson, Farago et al.: "Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling." in: The EMBO journal, Vol. 29, Issue 19, pp. 3236-48, 2010 (PubMed).

Schultz, Desbordes, Du et al.: "Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation." in: Molecular and cellular biology, Vol. 30, Issue 18, pp. 4521-34, 2010 (PubMed).

Ucisik-Akkaya, Davis, Do et al.: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, 2010 (PubMed).

Kim, Lim, Kim: "EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours." in: British journal of cancer, Vol. 102, Issue 2, pp. 436-46, 2010 (PubMed).

Wang, Zhao, Xiao et al.: "Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response." in: Stem cells (Dayton, Ohio), Vol. 27, Issue 6, pp. 1265-75, 2009 (PubMed).

Catalog No. ABIN689490

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