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Details for Product No. ABIN690103

Vascular Endothelial Growth Factor A (VEGFA) (Center) Peptide

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Protein Name
Synonyms MVCD1, VEGF, VPF, Vpf, Vegf, Vegf120, Vegf164, Vegf188, VEGF-A, VEGF164, eVEGF120, eVEGF164, vegf, vegfa, wu:fj82c06, vegf-a, vpf, vefg
Protein Region
Center
Application
Blocking Peptide (BP)
Pubmed 1 reference available
Catalog no. ABIN690103
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide
Alternative Name VEGFA
Background This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
Comment

Background: This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Shrivastava-Ranjan, Rollin, Spiropoulou: "Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin." in: Journal of virology, Vol. 84, Issue 21, pp. 11227-34, 2010 (PubMed).

Alternatives for antigen "Vascular Endothelial Growth Factor A (VEGFA)", type "Peptides"
Reactivities (1)
Beacon