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Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (Center), (Tyr224) Peptide

Details for Product No. ABIN690123, Supplier: Log in to see
Protein Name
  • MGC68466
  • cas
  • Crkas
  • p130cas
  • BCAR1
  • fc17f11
  • wu:fc17f11
  • zgc:175192
  • CAS
  • CAS1
  • CASS1
  • CRKAS
  • P130Cas
  • AI385681
  • Cas
  • P130CAS
  • breast cancer anti-estrogen resistance 1
  • breast cancer anti-estrogen resistance 1-like
  • bcar1
  • BCAR1
  • Bcar1
  • LOC100350323
Protein Region
Center, Tyr224
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Schuh, Guerrero, Schrecengost, Bouton: "BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2309-17, 2010 (PubMed).

Wendt, Smith, Schiemann: "p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity." in: The Journal of biological chemistry, Vol. 284, Issue 49, pp. 34145-56, 2009 (PubMed).

Qian, Li, Vass, Papageorge, Walker, Asnaghi, Steinbach, Tosato, Hunter, Lowy: "The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis." in: Cancer cell, Vol. 16, Issue 3, pp. 246-58, 2009 (PubMed).