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Protein Inhibitor of Activated STAT, 3 (PIAS3) (C-Term) Peptide

Details for Product No. ABIN690379, Supplier: Log in to see
Protein Name
  • PIAS3
  • Pias3l
  • ZMIZ5
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP1244a was selected from the C-term region of human PIAS3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background PIAS3 is a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, catalyzing the covalent attachment of a SUMO protein to specific target substrates. PIAS3 plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Nojiri, Joh, Miura et al.: "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3." in: Biochemical and biophysical research communications, Vol. 314, Issue 1, pp. 97-103, 2004 (PubMed).

Long, Wang, Matsuura et al.: "Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 1, pp. 99-104, 2004 (PubMed).

Ueki, Seki, Yano et al.: "Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)." in: Journal of human genetics, Vol. 44, Issue 3, pp. 193-6, 1999 (PubMed).