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Protein Inhibitor of Activated STAT, 3 (PIAS3) (N-Term) Peptide

Name

Protein Inhibitor of Activated STAT, 3 (PIAS3)
Synonyms ZMIZ5, FLJ14651, Pias3l, MGC27936, MGC81944, PIAS3, MGC165870
Binding Site

N-Term
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN690390
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for PIAS3 (N-term) antibody ABIN388057
Specificity The synthetic peptide sequence used to generate the antibody AP1245a was selected from the N-term region of human PIAS3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: PIAS3 is a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, catalyzing the covalent attachment of a SUMO protein to specific target substrates. PIAS3 plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Ueki, Seki, Yano et al.: "Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)." in: Journal of human genetics, Vol. 44, Issue 3, pp. 193-6, 1999 (PubMed).

Long, Wang, Matsuura et al.: "Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 1, pp. 99-104, 2004 (PubMed).

Nojiri, Joh, Miura et al.: "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3." in: Biochemical and biophysical research communications, Vol. 314, Issue 1, pp. 97-103, 2004 (PubMed).