PIASy1 (PIASy1) (N-Term) Peptide

Details for Product No. ABIN690427, Supplier: Log in to see
Protein Name
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP1249a was selected from the N-term region of human PIASy1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background PIASy1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. PIASy1 is involved in gene silencing, and promotes PARK7 sumoylation.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Imoto, Sugiyama, Muromoto, Sato, Yamamoto, Matsuda: "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 34253-8, 2003 (PubMed).

Liu, Gross, ten Hoeve, Shuai: "A transcriptional corepressor of Stat1 with an essential LXXLL signature motif." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 6, pp. 3203-7, 2001 (PubMed).

Liu, Liao, Rao, Kushner, Chung, Chang, Shuai: "Inhibition of Stat1-mediated gene activation by PIAS1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 18, pp. 10626-31, 1998 (PubMed).