Add to Basket Bulk discount
Order hotline:
+1 404 474 4654
+1 888 205 9894 (TF)

PIASy1 (PIASy1) (C-Term) Peptide

Name

PIASy1 (PIASy1)
Binding Site

C-Term
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN690438
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
Bulk discount
Shipping to
Availability Will be delivered in 2 to 3 Business Days

Additional Information
Application Details Publications back to top

Immunogen Synthetic peptide
Characteristics Blocking peptide for PIASy1 (C-term) antibody ABIN388062
Specificity The synthetic peptide sequence used to generate the antibody AP1250a was selected from the C-term region of human PIASy1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: PIASy1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. PIASy1 is involved in gene silencing, and promotes PARK7 sumoylation.

Application Details
Publications back to top

Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
Application Details back to top

Product Liu, Liao, Rao et al.: "Inhibition of Stat1-mediated gene activation by PIAS1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 18, pp. 10626-31, 1998 (PubMed).

Liu, Gross, ten Hoeve et al.: "A transcriptional corepressor of Stat1 with an essential LXXLL signature motif." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 6, pp. 3203-7, 2001 (PubMed).

Imoto, Sugiyama, Muromoto et al.: "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3." in: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 34253-8, 2003 (PubMed).