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La Ribonucleoprotein Domain Family, Member 7 (LARP7) (C-Term) Peptide

Details for Product No. ABIN690901, Supplier: Log in to see
Protein Name
  • LARP7
  • fa10g04
  • wu:fa10g04
  • zgc:56476
  • ALAZS
  • PIP7S
  • C330027G06Rik
  • D3Wsu161e
  • Larp7
  • La ribonucleoprotein domain family, member 7
  • La ribonucleoprotein domain family, member 7-like
  • LARP7
  • LOC100222278
  • LOC100356215
  • larp7
  • Larp7
  • Larp7l
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Background LARP7 is a negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Tyagi, Pearson, Karn: "Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction." in: Journal of virology, Vol. 84, Issue 13, pp. 6425-37, 2010 (PubMed).

Kalsi, Kuo, Aliev, Alexander, McMichael, Patterson, Walsh, Zhao, Schuckit, Nurnberger, Edenberg, Kramer, Hesselbrock, Tischfield, Vladimirov, Prescott, Dick, Kendler, Riley: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." in: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, 2010 (PubMed).

He, Jahchan, Hong, Li, Bayfield, Maraia, Luo, Zhou: "A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis." in: Molecular cell, Vol. 29, Issue 5, pp. 588-99, 2008 (PubMed).