BCL2-Related Protein A1 (BCL2A1) (BH3 Domain) Peptide

Details for Product No. ABIN690921, Supplier: Log in to see
Protein Name
  • BCL2A1
  • A1
  • BB218357
  • Bcl2a1
  • Bfl-1
  • Hbpa1
  • ACC-1
  • ACC-2
  • BCL2L5
  • BFL1
  • GRS
  • HBPA1
  • Bcl2a1d
  • BCL2-related protein A1
  • B cell leukemia/lymphoma 2 related protein A1a
  • BCL2A1
  • LOC100348952
  • Bcl2a1a
  • Bcl2a1
Protein Region
BH3 Domain
Peptide Type
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP1300a was selected from the region of human A1 BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Akatsuka, Nishida, Kondo, Miyazaki, Taji, Iida, Tsujimura, Yazaki, Naoe, Morishima, Kodera, Kuzushima, Takahashi: "Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens." in: The Journal of experimental medicine, Vol. 197, Issue 11, pp. 1489-500, 2003 (PubMed).

Akari, Bour, Kao, Adachi, Strebel: "The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors." in: The Journal of experimental medicine, Vol. 194, Issue 9, pp. 1299-311, 2001 (PubMed).