WD Repeat Domain 12 (WDR12) (Center) Peptide

Details for Product No. ABIN690993, Supplier: Log in to see
Protein Name
  • WDR12
  • YTM1
  • 4933402C23Rik
  • Ytm1
  • Ytm1p
  • fb24f09
  • wu:fb24f09
  • zgc:55609
  • WD repeat domain 12
  • WDR12
  • LOC100223280
  • Wdr12
  • wdr12
Protein Region
Peptide Type
Blocking Peptide (BP)
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Background This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications , Kathiresan, Voight, Purcell, Musunuru, Ardissino, Mannucci, Anand, Engert, Samani, Schunkert, Erdmann, Reilly, Rader, Morgan, Spertus, Stoll, Girelli, McKeown, Patterson, Siscovick, ODonnell, Elosua, Peltonen, Salomaa, Schwartz, Melander, Altshuler, Ard: "Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants." in: Nature genetics, Vol. 41, Issue 3, pp. 334-41, 2009 (PubMed).

Grimm, Hölzel, Rohrmoser, Harasim, Malamoussi, Gruber-Eber, Kremmer, Eick: "Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex." in: Nucleic acids research, Vol. 34, Issue 10, pp. 3030-43, 2006 (PubMed).

Hölzel, Rohrmoser, Schlee, Grimm, Harasim, Malamoussi, Gruber-Eber, Kremmer, Hiddemann, Bornkamm, Eick: "Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation." in: The Journal of cell biology, Vol. 170, Issue 3, pp. 367-78, 2005 (PubMed).