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Details for Product No. ABIN691064

Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term) Peptide

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Protein Name
Synonyms MCH2, Mch2, mCASP-6, xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6
Protein Region
C-Term
Application
Blocking Peptide (BP)
Pubmed 3 references available
Catalog no. ABIN691064
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP1313b was selected from the C-term region of human CASP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name CASP6
Background CASP6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.
Comment

Background: CASP6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications LeBlanc, Liu, Goodyer et al.: "Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 274, Issue 33, pp. 23426-36, 1999 (PubMed).

MacLachlan, El-Deiry: "Apoptotic threshold is lowered by p53 transactivation of caspase-6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 14, pp. 9492-7, 2002 (PubMed).

Sordet, Rébé, Dubrez-Daloz et al.: "Intracellular redistribution of procaspases during TPA-induced differentiation of U937 human leukemic cells." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 16, Issue 8, pp. 1569-70, 2002 (PubMed).

Alternatives for antigen "Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6)", type "Peptides"
Reactivities (5)
Beacon