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Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (C-Term) Peptide

Details for Product No. ABIN691064, Supplier: Log in to see
Protein Name
  • xCaspase-6
  • mch2
  • caspase-6
  • zgc:112960
  • CASP6
  • casp6
  • Mch2
  • mCASP-6
  • MCH2
  • caspase 6, apoptosis-related cysteine peptidase
  • caspase 6
  • caspase-6
  • Caspase-6
  • caspase-6-like
  • casp6
  • CASP6
  • CpipJ_CPIJ017008
  • Casp6
  • LOC100341546
  • LOC100517293
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP1313b was selected from the C-term region of human CASP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background CASP6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications MacLachlan, El-Deiry: "Apoptotic threshold is lowered by p53 transactivation of caspase-6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 14, pp. 9492-7, 2002 (PubMed).

Sordet, Rébé, Dubrez-Daloz, Boudard, Solary: "Intracellular redistribution of procaspases during TPA-induced differentiation of U937 human leukemic cells." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 16, Issue 8, pp. 1569-70, 2002 (PubMed).

LeBlanc, Liu, Goodyer, Bergeron, Hammond: "Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 274, Issue 33, pp. 23426-36, 1999 (PubMed).