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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 12 (ABCC12) (Center) Peptide

Details for Product No. ABIN691123, Supplier: Login to see
Protein Name
  • MRP9
  • 4930467B22Rik
Protein Region
Center
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13196c was selected from the Center region of ABCC12. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Yabuuchi, Shimizu, Takayanagi et al.: "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12." in: Biochemical and biophysical research communications, Vol. 288, Issue 4, pp. 933-9, 2001 (PubMed).