Ubiquitin B (UBB) (N-Term) Peptide
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| Synonyms |
MGC8385, FLJ25987, Ubc, Ubb2, Uba52, Rps27a, AL033289, UBC, UBB, Ubiquitin |
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Binding Site
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N-Term
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| Catalog no. |
ABIN691145 |
| Quantity |
0.1 mg |
| Price |
49.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Immunogen
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Synthetic peptide
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Characteristics
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Blocking peptide for UBB (N-term) antibody ABIN657141
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Specificity
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The synthetic peptide sequence used to generate the antibody AP13217a was selected from the N-term region of UBB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Comments
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Background: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
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Storage
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
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Restrictions
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For Research Use only
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Product
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Motegi, Liaw, Lee et al.: "Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 34, pp. 12411-6, 2008 (PubMed).
Tank, True: "Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates." in: PLoS genetics, Vol. 5, Issue 2, pp. e1000382, 2009 (PubMed).
Komander: "The emerging complexity of protein ubiquitination." in: Biochemical Society transactions, Vol. 37, Issue Pt 5, pp. 937-53, 2009 (PubMed).
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Alternatives for antigen "Ubiquitin B (UBB)", type "Peptides"
2013 BioMed Central Research Awards
