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Details for Product No. ABIN691243

WD Repeat Domain 45 (WDR45) (N-Term) Peptide

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Protein Name
Synonyms NBIA4, NBIA5, WDRX1, WIPI-4, WIPI4, JM5, Sfc19, Wdrx1, C79260, DXImx38e, zgc:56345, zgc:77017, MGC80694
Protein Region
N-Term
Application
Blocking Peptide (BP)
Pubmed 3 references available
Catalog no. ABIN691243
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13313a was selected from the N-term region of WDR45. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name WDR45
Background This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.
Comment

Background: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Clark, Glanowski, Nielsen et al.: "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios." in: Science (New York, N.Y.), Vol. 302, Issue 5652, pp. 1960-3, 2003 (PubMed).

Jeffries, Dove, Michell et al.: "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49." in: Molecular biology of the cell, Vol. 15, Issue 6, pp. 2652-63, 2004 (PubMed).

Proikas-Cezanne, Waddell, Gaugel et al.: "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy." in: Oncogene, Vol. 23, Issue 58, pp. 9314-25, 2004 (PubMed).

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