TAF8 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 43kDa (TAF8) (Center) Peptide

Details for Product No. ABIN691335
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Protein Name
Synonyms 43, II, TAF, TAFII-43, TAFII43, TBN, CG7128, Dmel\\CG7128, HL-VIII, Prodos, TAF8, TAF[[II]], TFIID, dmTAF8, l(1)16Fg, pds, pro, prod, tbn
Protein Region
Center
Application
Blocking Peptide (BP)
Pubmed 5 references available
Catalog no. ABIN691335
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13397c was selected from the Center region of TAF8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name TAF8
Background This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq].
Comment

Background: This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq].

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Guermah, Ge, Chiang et al.: "The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis." in: Molecular cell, Vol. 12, Issue 4, pp. 991-1001, 2003 (PubMed).

Soutoglou, Demény, Scheer et al.: "The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners." in: Molecular and cellular biology, Vol. 25, Issue 10, pp. 4092-104, 2005 (PubMed).

Chapuis, Hot, Hansmannel et al.: "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease...." in: Molecular psychiatry, Vol. 14, Issue 11, pp. 1004-16, 2009 (PubMed).

Soranzo, Spector, Mangino et al.: "A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium." in: Nature genetics, Vol. 41, Issue 11, pp. 1182-90, 2009 (PubMed).

Ganesh, Zakai, van Rooij et al.: "Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium...." in: Nature genetics, Vol. 41, Issue 11, pp. 1191-8, 2009 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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