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Details for Product No. ABIN691379

alpha Ketoglutarate Dehydrogenase (alphaKGDHC) (C-Term) Peptide

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Protein Name
Synonyms 2210403E04Rik, 2210412K19Rik, AA409584, d1401, mKIAA4192, AKGDH, E1k, OGDC
Protein Region
C-Term
Application
Blocking Peptide (BP)
Pubmed 2 references available
Catalog no. ABIN691379
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13442b was selected from the C-term region of OGDH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name OGDH
Background This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Comment

Background: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications McCartney, Rice, Sanderson et al.: "Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 24158-64, 1998 (PubMed).

Habelhah, Laine, Erdjument-Bromage et al.: "Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah." in: The Journal of biological chemistry, Vol. 279, Issue 51, pp. 53782-8, 2004 (PubMed).

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