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Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (N-Term) Peptide

Details for Product No. ABIN691454, Supplier: Log in to see
Protein Name
  • A3G
  • ARCD
  • ARP-9
  • ARP9
  • CEM-15
  • CEM15
  • bK150C2.7
  • dJ494G10.1
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP1351a was selected from the N-term region of human CEM15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background CEM15 is a member of the cytidine deaminase family. It is the product of one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. CEM15 has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Kao, Khan, Miyagi et al.: "The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity." in: Journal of virology, Vol. 77, Issue 21, pp. 11398-407, 2003 (PubMed).

Stopak, de Noronha, Yonemoto et al.: "HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability." in: Molecular cell, Vol. 12, Issue 3, pp. 591-601, 2003 (PubMed).

Mangeat, Turelli, Caron et al.: "Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts." in: Nature, Vol. 424, Issue 6944, pp. 99-103, 2003 (PubMed).

Zhang, Yang, Pomerantz et al.: "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA." in: Nature, Vol. 424, Issue 6944, pp. 94-8, 2003 (PubMed).

Wedekind, Dance, Sowden et al.: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." in: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, 2003 (PubMed).