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Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (Center, Glu133) Peptide

Name

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G)
Synonyms ARP9, CEM15, MDS019, FLJ12740, bK150C2.7, dJ494G10.1, APOBEC3G
Binding Site

Center, Glu133
5 references available
Certificates ISO 9001:2008
Catalog no. ABIN691455
Quantity 0.1 mg
Price 49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Characteristics Blocking peptide for CEM15 (Center E133) antibody ABIN388141
Specificity The synthetic peptide sequence used to generate the antibody AP1351b was selected from the Center region of human CEM15 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Comments

Background: CEM15 is a member of the cytidine deaminase family. It is the product of one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. CEM15 has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.

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Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Restrictions For Research Use only

Publications
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Product Wedekind, Dance, Sowden et al.: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." in: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, 2003 (PubMed).

Zhang, Yang, Pomerantz et al.: "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA." in: Nature, Vol. 424, Issue 6944, pp. 94-8, 2003 (PubMed).

Mangeat, Turelli, Caron et al.: "Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts." in: Nature, Vol. 424, Issue 6944, pp. 99-103, 2003 (PubMed).

Stopak, de Noronha, Yonemoto et al.: "HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability." in: Molecular cell, Vol. 12, Issue 3, pp. 591-601, 2003 (PubMed).

Kao, Khan, Miyagi et al.: "The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity." in: Journal of virology, Vol. 77, Issue 21, pp. 11398-407, 2003 (PubMed).

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Alternatives for antigen "Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G)", type "Peptides"
Reactivities Human (1)