You are viewing an incomplete version of our website. Please click to reload the website as full version.

Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (C-Term) Peptide

Details for Product No. ABIN691457, Supplier: Login to see New
New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Protein Name
Synonyms A3G, ARCD, ARP-9, ARP9, CEM-15, CEM15, bK150C2.7, dJ494G10.1
Protein Region
C-Term
Source
Synthetic
Peptide Type Synthetic
Application
Blocking Peptide (BP)
Pubmed 5 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Options
Shipping to United States ( )
Availability Will be delivered in 10 to 11 Business Days
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP1351d was selected from the C-term region of human CEM15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background CEM15 is a member of the cytidine deaminase family. It is the product of one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. CEM15 has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Kao, Khan, Miyagi et al.: "The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity." in: Journal of virology, Vol. 77, Issue 21, pp. 11398-407, 2003 (PubMed).

Stopak, de Noronha, Yonemoto et al.: "HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability." in: Molecular cell, Vol. 12, Issue 3, pp. 591-601, 2003 (PubMed).

Mangeat, Turelli, Caron et al.: "Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts." in: Nature, Vol. 424, Issue 6944, pp. 99-103, 2003 (PubMed).

Zhang, Yang, Pomerantz et al.: "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA." in: Nature, Vol. 424, Issue 6944, pp. 94-8, 2003 (PubMed).

Wedekind, Dance, Sowden et al.: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." in: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, 2003 (PubMed).

Catalog No. ABIN691457
$88.00
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)