H1 Histone Family, Member X (H1FX) (C-Term) Peptide

Details for Product No. ABIN691670
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Protein Name
Synonyms H1X, Gm461, cb1061, wu:fb12d01, wu:fb63d02, h1x, MGC53643, MGC130834, RGD1565596
Protein Region
C-Term
Application
Blocking Peptide (BP)
Pubmed 3 references available
Catalog no. ABIN691670
Quantity 0.1 mg
Price
49.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13731b was selected from the C-term region of H1FX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name H1FX
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H1 family.
Comment

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H1 family.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Takata, Matsunaga, Morimoto et al.: "H1.X with different properties from other linker histones is required for mitotic progression." in: FEBS letters, Vol. 581, Issue 20, pp. 3783-8, 2007 (PubMed).

Stoldt, Wenzel, Schulze et al.: "G1 phase-dependent nucleolar accumulation of human histone H1x." in: Biology of the cell / under the auspices of the European Cell Biology Organization, Vol. 99, Issue 10, pp. 541-52, 2007 (PubMed).

Warneboldt, Haller, Horstmann et al.: "Histone H1x is highly expressed in human neuroendocrine cells and tumours." in: BMC cancer, Vol. 8, pp. 388, 2009 (PubMed).

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