Vav 1 Oncogene (VAV1) (Center) Peptide
| Name |
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| Synonyms |
VAV, Vav, vav-T, vav1, MGC80607, VAV1 |
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Binding Site
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Center
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| Catalog no. |
ABIN691781 |
| Quantity |
0.1 mg |
| Price |
49.50 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Immunogen
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Synthetic peptide
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Characteristics
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Blocking peptide for VAV1 (Center) antibody ABIN657774
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Specificity
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The synthetic peptide sequence used to generate the antibody AP13853c was selected from the Center region of VAV1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
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Comments
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Background: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
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Storage
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Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
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Restrictions
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For Research Use only
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Product
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Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).
Barda-Saad, Shirasu, Pauker et al.: "Cooperative interactions at the SLP-76 complex are critical for actin polymerization." in: The EMBO journal, Vol. 29, Issue 14, pp. 2315-28, 2010 (PubMed).
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Alternatives for antigen "Vav 1 Oncogene (VAV1)", type "Peptides"
2013 BioMed Central Research Awards
