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tyrosine Kinase, Non-Receptor, 2 (TNK2) (Center), (Tyr284) Peptide

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Protein Name
Synonyms ACK, ACK-1, ACK1, p21cdc42Hs, AW552477, Ack, Cdgip, Pyk1
Protein Region
Center, Tyr284
Peptide Type Synthetic
Blocking Peptide (BP)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 10 to 11 Business Days
Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13936c was selected from the Center Y284 region of ACK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Mahajan, Mahajan: "Shepherding AKT and androgen receptor by Ack1 tyrosine kinase." in: Journal of cellular physiology, Vol. 224, Issue 2, pp. 327-33, 2010 (PubMed).

Chua, Lim, Tham et al.: "Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells." in: Molecular oncology, Vol. 4, Issue 4, pp. 323-34, 2010 (PubMed).

Prieto-Echagüe, Gucwa, Craddock et al.: "Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1." in: The Journal of biological chemistry, Vol. 285, Issue 14, pp. 10605-15, 2010 (PubMed).

Catalog No. ABIN691856
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