D-Amino-Acid Oxidase (DAO) (Center) Peptide

Details for Product No. ABIN691860
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Protein Name
Synonyms DAAO, DAMOX, OXDA, DAO, 1600012D06Rik, Abp1, Abp, Dao, daao, oxda, damox, dao, DKFZp469N2232, zgc:77858, zgc:76928, SC5F2A.23c, wu:fb55b11, zgc:113922, MGC114783
Protein Region
Center
Application
Blocking Peptide (BP)
Pubmed 1 reference available
Catalog no. ABIN691860
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide
Specificity The synthetic peptide sequence used to generate the antibody AP13941c was selected from the Center region of DAO. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Alternative Name DAO
Background This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known, it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.
Comment

Background: This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known, it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia.

Restrictions For Research Use only
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Mitchell, Paul, Chen et al.: "Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 16, pp. 7556-61, 2010 (PubMed).

Reactivities (1), (1), (1)
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