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Jumonji Domain Containing 6 (JMJD6) (C-Term) Peptide

Details for Product No. ABIN692087, Supplier: Log in to see
Protein Name
  • GB15204
  • jmjd6
  • ptdsr
  • PTDSR
  • PSR
  • PTDSR1
  • 5730436I23Rik
  • D11Ertd195e
  • PtdSerR
  • Ptdsr
  • mKIAA0585
  • psr
  • zfpsr
  • zgc:66264
  • ptdsr1
  • cg5383
  • jumonji domain containing 6
  • phosphatidylserine receptor
  • LOC100230335
  • PSR
  • AaeL_AAEL008084
  • AaeL_AAEL013254
  • AaeL_AAEL013632
  • CpipJ_CPIJ004848
  • CpipJ_CPIJ019866
  • jmjd6
  • JMJD6
  • Jmjd6
  • jmjd6-a
  • jmjd6-b
Protein Region
C-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP14160b was selected from the C-term region of JMJD6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Background This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells, however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Hong, Zang, White, Wang, Pan, Zhao, Murphy, Dai, Henson, Kappler, Hagman, Zhang: "Interaction of JMJD6 with single-stranded RNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 33, pp. 14568-72, 2010 (PubMed).

Mantri, Krojer, Bagg, Webby, Butler, Kochan, Kavanagh, Oppermann, McDonough, Schofield: "Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6." in: Journal of molecular biology, Vol. 401, Issue 2, pp. 211-22, 2010 (PubMed).

Webby, Wolf, Gromak, Dreger, Kramer, Kessler, Nielsen, Schmitz, Butler, Yates, Delahunty, Hahn, Lengeling, Mann, Proudfoot, Schofield, Böttger: "Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing." in: Science (New York, N.Y.), Vol. 325, Issue 5936, pp. 90-3, 2009 (PubMed).

Zakharova, Dadsetan, Fomina: "Endogenous Jmjd6 gene product is expressed at the cell surface and regulates phagocytosis in immature monocyte-like activated THP-1 cells." in: Journal of cellular physiology, Vol. 221, Issue 1, pp. 84-91, 2009 (PubMed).